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Status epilepticus; treatment of epileptic seizures (generalized - absences, myoclonic seizures, tonic-clonic, atonic, mixed; partial - simple, complex, secondary generalized seizures; specific syndromes (West, Lennox-Gastaut).
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Home Nervous system Convulex 500 (Valproic acid),100
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Used for diabetes.
LYUMJEV® 100 Einheiten/ml KwikPen™(insulin lispro),5×3 ml €122.12
Austria

Convulex 500 (Valproic acid),100

€0.00

Status epilepticus; treatment of epileptic seizures (generalized – absences, myoclonic seizures, tonic-clonic, atonic, mixed; partial – simple, complex, secondary generalized seizures; specific syndromes (West, Lennox-Gastaut).

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SKU: Gedeapmedi4 Category: Nervous system
Brands: biomo pharma GmbH
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Description

 

Pharmacological action

Convulex® — an antiepileptic drug that also has a central muscle relaxant and sedative effect. The mechanism of action is primarily due to inhibition of the enzyme GABA-transferase and an increase in the content GABA in < span title="central nervous system">CNS. GABA inhibits pre- and postsynaptic discharges and, thereby, prevents the spread of seizure activity in CNS.

In addition, in the mechanism of action of the drug, a significant role belongs to the effect of valproic acid on the receptors GABAA, as well as the effect on voltage-dependent sodium channels. According to another hypothesis, it acts on the sites of postsynaptic receptors, simulating or enhancing the inhibitory effect of GABA. A possible direct effect on membrane activity is associated with changes in potassium conductance. Improves the mental state and mood of patients, has antiarrhythmic activity.

Pharmacokinetics

Equilibrium concentration when in/in is achieved within a few minutes and can be maintained with a slow infusion. The therapeutic concentration of the drug in blood plasma ranges from 50 to 150 mg/l. Valproic acid is bound to plasma proteins by 90–95% — at a concentration in blood plasma of up to 50 mg/l and by 80–85% — at a concentration of 50–100 mg/l; with uremia, hypoproteinemia and cirrhosis, protein binding is reduced.

Concentration levels in cerebrospinal fluid correlate with the non-protein bound fraction of the drug, being approximately 10% of serum levels.

Valproic acid penetrates the placental barrier and is excreted in breast milk. The concentration in breast milk is 1–10% of the concentration in the mother’s blood plasma.

The drug undergoes glucuronidation and oxidation in the liver, metabolites and unchanged valproic acid (1-3% of the dose) are excreted by the kidneys, small amounts are excreted in feces and exhaled air. T< sub>1/2of the drug is in healthy subjects and with monotherapy from 8 to 20 hours; when combined with other Drug,T1/2 can be 6– 8 hours due to induction of metabolic enzymes; in patients with impaired liver function and elderly patients — may be significantly longer.

Indications

Status epilepticus; treatment of epileptic seizures (generalized — absences, myoclonic seizures, tonic-clonic, atonic, mixed; partial — simple, complex, secondary generalized seizures; specific syndromes (West, Lennox-Gastaut).

Contraindications

  • hypersensitivity to valproic acid;
  • severe dysfunction of the liver and/or pancreas;
  • porphyria;
  • hemorrhagic diathesis;
  • severe thrombocytopenia.

With caution:

  • in children when treated with several antiepileptic drugs;
  • in children and adolescents with multiple comorbidities and severe forms of seizures;
  • for renal dysfunction;
  • in patients with anamnestic data on diseases of the liver and pancreas;
  • in case of suppression of bone marrow hematopoiesis: leukopenia, anemia, thrombocytopenia;
  • for congenital enzymopathies;
  • for organic brain lesions;
  • with hypoproteinemia.
Additional information
Weight 0.10 kg
Producing country

Austria

Manufacturer

biomo pharma GmbH

Dosage form

Capsules

Usage

Unisex

Package

Box

EAN

Ap-13358588

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  • Thiocodin, 15 mg + 300 mg/10 ml, 100, Tiokodyna, 15 mg + 300 mg/10 ml, 100, UNIA
  • Antidol 15, 500 mg + 15 mg, 10
  • Maxigra Go 25mg, 8
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