Hydrea (Hydroxycarbamide), 100

indication
The drug is a cytostatic. It affects the growth of malignant cells.
Your doctor has prescribed it for you to treat blood cancers (chronic myeloid leukemia, essential thrombocythemia and polycythemia vera).
contraindication
The drug should not be taken
if you are allergic (hypersensitive) to hydroxycarbamide or any of the other ingredients of this medicine. If hypersensitivity occurs during treatment, stop therapy and inform your doctor;
if you do not have enough blood cells (bone marrow depression, leukopenia, thrombocytopenia, severe anemia);
if you have recently been vaccinated with a so-called “live vaccine” (for example, against yellow fever);
if you are pregnant or breastfeeding.
Dosage of hydrea
Always take this medicine exactly as your doctor has told you. Please check with your doctor or pharmacist if you are not sure.
Therapy can only be carried out by experienced doctors who specialize in oncology (cancer diseases) or hematology (blood diseases).
In chronic myeloid leukemia, the initial dose is usually 40 mg/kg of body weight per day. Then the dose is selected individually, depending on the number of blood cells.
With true polycythemia, the dose is usually 15-20 mg / kg of body weight per day. Then the dose is selected individually, usually up to 1-2 capsules (500-1000 mg) per day.
In essential thrombocythemia, the dose is usually 15 mg/kg body weight per day with rapid individual dose adjustment.
Dosage in children
Because these disorders are rare in children, dosing regimens cannot be established at this time.
Dosing in Elderly Patients
Elderly patients may be more sensitive to the effects of hydroxyurea and may require a lower dose.
Dosage in patients with hepatic or renal insufficiency
For patients with hepatic and/or renal insufficiency, no specific dosage recommendations can be given.
How long should the drug be used?
A reasonable period of time during which the attending physician can get an idea about the effectiveness of the drug is 6 weeks. If the effectiveness of hydroxyurea is proven, therapy should be continued indefinitely. With the progression of the disease or the appearance of signs of intolerance, therapy should be discontinued.
Your doctor will regularly check your blood work and liver and kidney function during therapy.
If you take more than you should
If you take more capsules than prescribed, contact your doctor or hospital immediately. The attending physician can decide on the necessary measures depending on the severity of the poisoning. Skin and mucosal reactions may occur as a sign of an overdose.
If you forget to take a dose
If you forget to use it, seek the advice of your doctor. Do not take a double dose if you have forgotten the previous dose.
If you stop taking it
Use the drug as directed by your doctor or as directed by your doctor for dosage instructions. Do not change the dosage yourself.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.pregnancy
If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
pregnancy
In animal experiments, the active substance hydroxyurea had a strong embryo-damaging effect.
Therefore, the medicine should not be used during pregnancy. If the doctor considers the use during pregnancy absolutely necessary, you should consult your doctor about the risk of harmful effects to your child associated with treatment.
Women of childbearing age should use effective contraception before and during treatment with hydroxycarbamide. If you become pregnant during treatment, tell your doctor immediately and seek genetic counseling.
lactation
You should not use the drug while breastfeeding. If your doctor deems it necessary to use it while breastfeeding, you should stop breastfeeding.
fertility
The active ingredient hydroxycarbamide can damage your genetic material.
Appropriate contraceptive measures should be taken if the partner is being treated with the drug. Women should not become pregnant during treatment.
Men receiving hydroxyurea treatment are advised not to have children during treatment and for at least 6 months thereafter. Advice on sperm preservation should be sought before starting therapy due to the risk of permanent infertility as a result of therapy.
Patients of childbearing age should use effective contraception during therapy and for at least 6 months after therapy.
Hydroxyurea is mutagenic, so prior genetic counseling is recommended, even if you want to have children after therapy.
on a way
The capsules should be swallowed whole with plenty of liquid (eg a glass of water) without dissolving in the mouth.
Interactions in Hydrea
Taking with other medicines
Please tell your doctor or pharmacist if you are taking/using, have recently taken/have used or may be taking/using any other medicines, even if they are available without a prescription.
Hydroxycarbamide should be used with caution in patients who have received other cytotoxic drugs or radiation therapy at the same time as, or prior to, treatment. Side effects may occur more frequently and more severely in these patients. It is possible to increase erythema (redness of the skin) with simultaneous or previous irradiation.
The risk of inflammation of blood vessels in the skin (cutaneous vasculitis), including ulceration and destruction of blood vessels, is increased in patients who have received prior or concomitant interferon therapy.
Inflammation of the pancreas (pancreatitis) and liver damage, sometimes fatal, as well as severe nerve damage in the legs and arms (peripheral neuropathy) have been reported with concomitant treatment with hydroxycarbamide and antiretroviral agents (so-called nucleoside analogues, HIV drugs). infections). The combination of hydroxycarbamide with a nucleoside analog a cannot be recommended.
During the use of the drug should not be vaccinated with live vaccines, as this can lead to serious infections.
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